Julia Hum, Ph.D.
Assistant Professor of Physiology

(317) 955-6265
jmhum@marian.edu
Evans Center, Room 312A

Biography

Julia Hum, Ph.D., is an Assistant Professor of Physiology at the Marian University School of Osteopathic Medicine. She earned a B.S. in Biology from Saint Mary's College, Notre Dame, IN. and a Ph.D. in Cellular and Integrative Physiology from Indiana University School of Medicine. She completed her thesis research under the mentorship of Dr. Fredrick Pavalko in the area of cellular signaling that promotes and inhibits the anabolic response of bone cells to mechanical loading. She then completed her postdoctoral studies investigating phosphate regulation by the hormone Fibroblast growth factor 23 (FGF23) in both common and rare diseases in the medical and molecular genetics laboratory of Dr. Kenneth White at the Indiana University School of Medicine.

During her graduate and postdoctoral training Dr. Hum was awarded fellowships based on both on her teaching skills and research proposals. She was selected as a National Science Foundation (NSF) Teaching Fellow for the GK-12 Urban Educators program, and was an invited teaching assistant for a Woods Hole microscopy workshop. She was awarded the American Society for Bone and Mineral Research's (ASBMR) Young Investigator Award. Dr. Hum was selected as an ASBMR Endocrine Fellow during her postdoctoral training and was awarded a research fellowship from the American Heart Association (AHA).

Dr. Hum lives in Indianapolis with her husband and their three young daughters. Having grown up in the Hoosier state, she's a lifelong basketball fan and former collegiate player. She cherishes time spent with her young family and enjoys participating in science outreach activities.

Clinical/Research Interests

Dr. Hum's primary research area is bone biology, her research goals include investigating how osteoblasts and osteocytes communicate in response to mechanical and hormonal signaling.

Highlighted Publications

Hum, J.M., O’Bryan, L.M., Tatiparthi, A., Clinkenbeard, E.L., Ni, P., Cramer, M.S., Bhaskaran, M., Johnson, R.L., Wilson, J.M., Smith, R.C., White, K.E. (2019) Sustained Klotho Delivery Reduces Serum Phosphate in a Model of Diabetic Nephropathy. Journal of Applied Physiology – In Press

Shadmand, M., Jackson, K., Bender, C., Donnelly, S., Guan, H., Tobin, K., Yates, S., Hum, J.M., Lowery, J.W. (2018) Bringing attention to lesser-known bone remodeling pathways. Clinical Reviews in Bone and Mineral Metabolism 16(3):95-102.

Hum, J.M., O’Bryan, L.M., Tatiparthi, A., Johnson, R.L., Wilson, J.M., Clinkenbeard, E.L., Cass, T.A., Smith, R.C., White, K.E. (2017). Chronic Hyperphosphatemia and Vascular Calcification Are Reduced by Stable Delivery of Soluble Klotho. JASN Apr;28(4):1162-1174.​

Hum, J.M., Clinkenbeard, E.L., Cass, T.A., White, K.E. (2017) The Metabolic Bone Disease Associated with the Hyp Mutation is Independent of Osteoblastic HIF1alpha Expression. Bone Reports Jan 17;6:38-43.​

Clinkenbeard, E.L., Stayrook, K.R., Farrow, E.G., Cass, T.A., Summers, L.J., Ip, C.S., Appaiah, H.N., Hum, J.M., Ivan, M., Richine, B.M., Goodwin, C.B., Chan, R.J., Schipani, E., Clemens, T.L., White, K.E. (2017) Erythropoietin Stimulates Murine and Human Fibroblast Growth Factor-23, Revealing Novel Roles for Bone and Bone Marrow. Haematologica. Nov;102(11):e427-e430.

​White, K.E., Hum, J.M., Econs, M.J., (2014) Hypophosphatemic Rickets: Revealing Novel Control Points for Phosphate Homeostasis. Curr Osteoporos Rep 3, 252-262.

Hum, J.M., Day, R.N., Bidwell, J.P., Wang, Y., Pavalko, F.M. (2014) Mechanical Loading in Osteocytes Induces the Formation of a Src/Pyk2/MBD2 Complex that Suppresses Anabolic Gene Expression. PLoS ONE 5, e97942.

Hum, J.M., Siegel, A.P., Pavalko, F.M., Day, R.N. (2012) Monitoring Biosensor Activity in Living Cells with Fluorescence Lifetime Imaging Microscopy. Int J Mol Sci 11, 14385-14400.

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