During the early career of Dr. Klabunde (1970-1985), his research focused on metabolism-linked regulation of blood flow in skeletal muscle, particularly on the role of oxygen and adenosine. Over the next 22 years, he studied the mechanisms of action of various cardiovascular drugs in animal models of heart failure and septic shock, the efficacy of different types of thrombolytic agents, and the mechanisms by which nitric oxide regulates cardiac contractile function and microcirculatory function. Most of the cardiac work was performed using isolated, Langendorff-perfused rat and mouse hearts. The last few years of his research focused on how diabetes and obesity affect nitric oxide, endothelin and adrenergic control of the coronary circulation.
Dr. Klabunde ended his laboratory research a several years ago to concentrate on other scholarly activities, including writing textbooks, managing the content of teaching websites, and serving as a consultant for cardiovascular research and teaching.
Hopper M, Tune J, Klabunde R. Small-group activity to reinforce the impact of valvular defects and heart failure on cardiac pressure-volume relationships. MedEdPORTAL 14:10675, 2018.
Klabunde, RE. Cardiac electrophysiology: normal and ischemic ionic currents and the ECG. Adv Physiol Educ 41: 29-37, 2017.
Wilson, TE, RE Klabunde and KD Monahan. Using thermal stress to model aspects of disease states. J Thermal Biol 43: 24–32, 2014.
Klabunde, RE, AD LePorte and TE Wilson. Effect of temperature on isoproterenol-induced increases in left ventricular developed pressure.J Thermal Biol, 38:369-373, 2013.
Klabunde, RE. Normal and Abnormal Blood Pressure (Physiology, Pathophysiology and Treatment). Amazon Kindle book, 2013.
Klabunde, RE. Cardiovascular Physiology Concepts. Lippincott Williams & Wilkins/Baltimore, 2005 (1st edition) and 2012 (2nd edition). A textbook for medical and allied health science students.
Klabunde, RE. Cardiovascular Physiology Concepts, www.cvphysiology.com (1999-2019) and Cardiovascular Pharmacology Concepts, www.cvpharmacology.com (2006-2019).
Klabunde, RE. Teaching physiology to 21st century medical students. The Physiologist 56:1-4, 2013.
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